The
research in this section is focused on understanding translational regulatory
mechanisms and the molecular details of the initiation of protein synthesis
in eukaryotic cells. A current focus of study is the eukaryotic translation
initiation factor 5B (eIF5B), a GTPase required for ribosomal subunit joining.
We are also studying how the function of eIF2 is regulated by phosphorylation,
focusing on determinants of substrate recognition by the eIF2a protein kinases and the structure and regulation of these enzymes.
- Molecular, Biochemical, and Structural Analysis of eIF5B/IF2, a Universally Conserved Translation Initiation Factor
- Molecular Genetic Analysis of Translational Regulation by eIF2a Phosphorylation
